BMEN90033 · Week 7
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BMEN90033 · WEEK 7 · BIOINSTRUMENTATION

The Pupillary Light Reflex.

The iris constricts under increased illuminance and dilates when illuminance falls. The response is well modelled as a first-order lag preceded by a transport delay, giving a transfer function with a single pole and an exponential delay term.

first order transport delay step response
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01physiological model

Input illuminance, output pupil area.

Retinal photoreceptors encode the illuminance $L(t)$ and signal the pretectal nucleus. Efferent parasympathetic fibres then drive the sphincter pupillae to contract, reducing the pupil area $A(t)$. The afferent and efferent pathway together introduces a transport delay $T_d$ of approximately $180$ to $250\text{ ms}$ before any movement is observed.

The iris musculature is over-damped and is well approximated as a first-order lag with time constant $\tau \approx 200$ to $300\text{ ms}$. Combining the delay and the lag gives the linear model

$$\tau\,\frac{da(t)}{dt} + a(t) = -K\,L(t - T_d),$$

where $a(t) = A(t) - A_0$ is the deviation of pupil area from its dark-adapted resting value $A_0$. The negative sign reflects the inverse relationship between illuminance and pupil area. The gain $K$ has units of area per unit illuminance.

Separation of effects. The delay $T_d$ and the time constant $\tau$ arise from distinct mechanisms. $T_d$ is dominated by neural conduction and synaptic transmission; $\tau$ is set by the mechanical properties of the iris musculature. The delay shifts the input in time; the lag governs the rate of approach to steady state.
anatomy · input L(t) · output A(t)
02transfer function

Derivation via the Laplace transform.

Apply the Laplace transform to both sides of the governing ODE under zero initial conditions, $a(0) = 0$. The derivative maps to multiplication by $s$, and the delayed input $L(t - T_d)$ maps to $e^{-T_d s}\,L(s)$ by the time-shift property.

showderivation · 3 steps

Step 1 · transform the ODE

$$\tau\,s\,A(s) + A(s) = -K\,e^{-T_d s}\,L(s).$$

Step 2 · factor $A(s)$

$$A(s)\,(\tau s + 1) = -K\,e^{-T_d s}\,L(s).$$

Step 3 · form the ratio

Divide through to obtain the transfer function $G(s) = A(s)/L(s)$:

$$G(s) = \frac{A(s)}{L(s)} = \frac{-K\,e^{-T_d s}}{\tau s + 1}.$$

The expression separates into three factors: a static gain $-K$, a first-order lag $1/(\tau s + 1)$ with a single pole at $s = -1/\tau$, and a transport-delay term $e^{-T_d s}$. The delay term contributes no poles or zeros but adds a phase lag of $\omega T_d$ at each frequency.

Irrational transfer function. Because $e^{-T_d s}$ is not a ratio of polynomials, $G(s)$ is not rational. The pole-zero diagram represents only the rational part; the delay is recorded separately as a phase term.
s-plane · rational part of G(s)
stable
unstable
$\mathrm{Re}(s)$
$\mathrm{Im}(s)$
delay factor  $e^{-T_d\,s}$  contributes phase only, no pole or zero
× pole stable half-plane
03time-domain response

Response to step and periodic inputs.

For an illuminance step of size $L_0$ applied at $t = 0$, the inverse Laplace transform gives

$$a(t) = \begin{cases} 0, & t < T_d, \\[4pt] -K L_0\bigl(1 - e^{-(t-T_d)/\tau}\bigr), & t \ge T_d. \end{cases}$$

The output remains zero for $t < T_d$, since the signal has not yet reached the iris. For $t \ge T_d$ the pupil area decays exponentially toward the steady-state value $A_\infty = A_0 - K L_0$, closing approximately $63\%$ of the remaining gap per time constant $\tau$. The pupil in the adjacent panel is driven by this model directly: the ring diameter is recomputed from $a(t)$ at each frame.

The preset row selects alternative input waveforms: square-wave flashing, sinusoidal modulation, a brief single pulse, and a linear ramp. For periodic inputs the steady-state output follows the frequency response $G(j\omega) = -K\,e^{-j\omega T_d}/(1 + j\omega\tau)$. Once the driving frequency exceeds $\omega_c = 1/\tau$, the lag attenuates each cycle and the pupil ceases to track the input faithfully.

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1.50 Hz
0.20 s
0.25 s
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illuminance $L$
area $A(t)/A_0$
time
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Frequency response. At low flash frequencies the pupil tracks each edge with a first-order constriction transient. For $f$ above $1/(2\pi\tau)$ the amplitude of the tracked oscillation falls off at $-20\text{ dB/decade}$, following $|G(j\omega)| = K/\sqrt{1 + (\omega\tau)^2}$. The delay $T_d$ adds only phase lag $\omega T_d$ and does not affect magnitude.
pupil · illuminance · area trace
first-order lag with transport delay